A skin biopsy is a versatile procedure that can be used to diagnose a wide range of skin conditions, including but not limited to infections, inflammatory disorders, autoimmune diseases, and various types of skin cancer. However, while a skin biopsy is highly valuable for providing insights into many skin conditions, it may not be suitable for diagnosing certain conditions that primarily affect deeper layers of the skin or require other diagnostic approaches, such as imaging studies or blood tests.

A skin biopsy procedure is typically performed using local anesthesia to minimize discomfort, so it is generally well-tolerated and causes minimal pain. After the procedure, patients may experience some mild discomfort or soreness at the biopsy site, but this usually subsides quickly.